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2010 Sep 1
CAS Number: 97540-22-2
Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1
Dexamethasone is a type of steroid medication
IC50 > 30 μM)
RD162 ipine (hydrochloride) 2010 Sep 1IC50: 30. 9 nM RD162 is an androgen receptor (AR) antagonist. Metastatic prostate cancer is treated with drugs antagonizinf androgen action, but most patients progress to a more aggressive form of the disease named castration resistant prostate cancer, driven by elevated expression of the androgen receptor (AR). In vitro: RD162 was optimized from a screen for nonsteroidal antiandrogens retaining activity in the setting of increased androgen receptor
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